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The following term was not found in PubMed: ENSG00000101574
Page 1
RNA m6A methylation across the transcriptome.
Sendinc E, Shi Y. Sendinc E, et al. Mol Cell. 2023 Feb 2;83(3):428-441. doi: 10.1016/j.molcel.2023.01.006. Mol Cell. 2023. PMID: 36736310 Free article. Review.
N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Hao Z, Wu T, Cui X, Zhu P, Tan C, Dou X, Hsu KW, Lin YT, Peng PH, Zhang LS, Gao Y, Hu L, Sun HL, Zhu A, Liu J, Wu KJ, He C. Hao Z, et al. Mol Cell. 2020 May 7;78(3):382-395.e8. doi: 10.1016/j.molcel.2020.02.018. Epub 2020 Mar 16. Mol Cell. 2020. PMID: 32183942 Free PMC article.
The level of 6mA in HepG2 mtDNA is at least 1,300-fold higher than that in gDNA under normal growth conditions, corresponding to approximately four 6mA modifications on each mtDNA molecule. METTL4, a putative mammalian methyltransferase, can mediate mtDNA 6mA methylation, …
The level of 6mA in HepG2 mtDNA is at least 1,300-fold higher than that in gDNA under normal growth conditions, corresponding to approximate …
METTLing in Stem Cell and Cancer Biology.
Tooley JG, Catlin JP, Tooley CES. Tooley JG, et al. Stem Cell Rev Rep. 2023 Jan;19(1):76-91. doi: 10.1007/s12015-022-10444-7. Epub 2022 Sep 12. Stem Cell Rev Rep. 2023. PMID: 36094754 Free PMC article. Review.
METTL1, METTL5, METTL6, METTL8, and METTL17 also have recently identified roles in ESC pluripotency and differentiation, while METTL11A/11B, METTL4, METTL7A, and METTL22 have been shown to play roles in neural, mesenchymal, bone, and hematopoietic stem cell development, re …
METTL1, METTL5, METTL6, METTL8, and METTL17 also have recently identified roles in ESC pluripotency and differentiation, while METTL11A/11B, …
N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells.
Shen M, Li Y, Wang Y, Shao J, Zhang F, Yin G, Chen A, Zhang Z, Zheng S. Shen M, et al. Redox Biol. 2021 Nov;47:102151. doi: 10.1016/j.redox.2021.102151. Epub 2021 Sep 26. Redox Biol. 2021. PMID: 34607160 Free PMC article.
Here, we report that the total levels of N(6)-methyladenosine (m(6)A) modification are evidently increased upon exposure to ferroptosis-inducing compounds due to the upregulation of methylase METTL4 and the downregulation of demethylase FTO. Interestingly, RNA-seq shows th …
Here, we report that the total levels of N(6)-methyladenosine (m(6)A) modification are evidently increased upon exposure to ferroptosis-indu …
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting.
Qi YN, Liu Z, Hong LL, Li P, Ling ZQ. Qi YN, et al. J Hematol Oncol. 2023 Aug 2;16(1):89. doi: 10.1186/s13045-023-01477-7. J Hematol Oncol. 2023. PMID: 37533128 Free PMC article. Review.
The most typical family member METTL3/METTL14 forms a methyltransferase complex involved in N6-methyladenosine (m6A) modification of RNA, regulating tumor proliferation, metastasis and invasion, immunotherapy resistance, and metabolic reprogramming of tumor cells. METTL1, METT …
The most typical family member METTL3/METTL14 forms a methyltransferase complex involved in N6-methyladenosine (m6A) modification of RNA, re …
METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets.
Hsu KW, Lai JC, Chang JS, Peng PH, Huang CH, Lee DY, Tsai YC, Chung CJ, Chang H, Chang CH, Chen JL, Pang ST, Hao Z, Cui XL, He C, Wu KJ. Hsu KW, et al. Genome Biol. 2022 Dec 2;23(1):249. doi: 10.1186/s13059-022-02819-3. Genome Biol. 2022. PMID: 36461076 Free PMC article.
CONCLUSIONS: We show that hypoxia results in enriched 6mA levels in mammalian tumor cells through METTL4. This METTL4-mediated nuclear 6mA deposition induces tumor metastasis through activating multiple metastasis-inducing genes. METTL4 is characterized as a …
CONCLUSIONS: We show that hypoxia results in enriched 6mA levels in mammalian tumor cells through METTL4. This METTL4-mediated …
Structural insights into molecular mechanism for N(6)-adenosine methylation by MT-A70 family methyltransferase METTL4.
Luo Q, Mo J, Chen H, Hu Z, Wang B, Wu J, Liang Z, Xie W, Du K, Peng M, Li Y, Li T, Zhang Y, Shi X, Shen WH, Shi Y, Dong A, Wang H, Ma J. Luo Q, et al. Nat Commun. 2022 Sep 26;13(1):5636. doi: 10.1038/s41467-022-33277-x. Nat Commun. 2022. PMID: 36163360 Free PMC article.
METTL4 belongs to a subclade of MT-A70 family members of methyltransferase (MTase) proteins shown to mediate N(6)-adenosine methylation for both RNA and DNA in diverse eukaryotes. ...Structural comparison of METTL4 with the mRNA m6A enzyme METTL3/METTL14 heterodimer …
METTL4 belongs to a subclade of MT-A70 family members of methyltransferase (MTase) proteins shown to mediate N(6)-adenosine methylati …
RNA modification m6Am: the role in cardiac biology.
Benak D, Kolar F, Zhang L, Devaux Y, Hlavackova M. Benak D, et al. Epigenetics. 2023 Dec;18(1):2218771. doi: 10.1080/15592294.2023.2218771. Epigenetics. 2023. PMID: 37331009 Free PMC article. Review.
N(6),2'-O-dimethyladenosine (m(6)Am) is one of the most prevalent chemical marks on RNA and is dynamically regulated by writers (PCIF1, METTL4) and erasers (FTO). The presence or absence of m(6)Am in RNA affects mRNA stability, regulates transcription, and modulates pre-mR …
N(6),2'-O-dimethyladenosine (m(6)Am) is one of the most prevalent chemical marks on RNA and is dynamically regulated by writers (PCIF1, M …
METTL4 mediated-N6-methyladenosine promotes acute lung injury by activating ferroptosis in alveolar epithelial cells.
Sang A, Zhang J, Zhang M, Xu D, Xuan R, Wang S, Song X, Li X. Sang A, et al. Free Radic Biol Med. 2024 Mar;213:90-101. doi: 10.1016/j.freeradbiomed.2024.01.013. Epub 2024 Jan 14. Free Radic Biol Med. 2024. PMID: 38224757
Thus, we generated METTL4 deficiency mice and found that METTL4 knockdown alleviated ferroptosis, as evidenced by lipid ROS, MDA, Fe(2+), as well as alterations in GPX4 and SLC7A11 protein expression. Consistently, we found that METTL4 silencing could decreas …
Thus, we generated METTL4 deficiency mice and found that METTL4 knockdown alleviated ferroptosis, as evidenced by lipid ROS, M …
60 results